Prozac is an antidepressant drug that has several side effects if it is consumed excessively. Mixing Prozac with alcohol can lead to some dire consequences which can be avoided with the right amount of caution. Drinking alcohol while taking Prozac can also interfere with treatment for depression and/or anxiety. Side Effects of Mixing Alcohol, Depression, and Prozac Alcohol may temporarily seem to elevate moods and decrease depressive symptoms; however, it can actually make these symptoms worse when it wears off. Unfortunately, if they are already taking an antidepressant like Prozac, the mixture can lead to an increased risk of a life-threatening overdose or the development of an alcohol dependence disorder. If you mix antidepressants and alcohol: You may feel more depressed or anxious. Drinking can counteract the benefits of your antidepressant medication, making your symptoms more difficult to treat. Prozac can interfere with coordinated movement and alertness, like alcohol does. Combining Prozac with alcohol can quickly lead to increased sedation. Having even one drink while you take Prozac. When Can You Drink Alcohol Again? Unlike with many other medications, a patient cannot simply wait a few hours after taking Prozac to drink. This is because Prozac has a fairly long half-life in the body, and will remain as a metabolite for quite some time. There are also possible dangers and interactions of mixing alcohol and Prozac including worsening symptoms of depression, a decline in the effectiveness of the medicine and symptoms like drowsiness and sedation. Mixing Prozac and alcohol can increase the user’s heart rate and blood pressure to unsafe levels. It can also make depression much worse if done regularly. It can also make depression much worse if done regularly. Since alcohol and Prozac (fluoxetine hydrochloride) act upon similar chemicals in the brain, the antidepressant may intensify the effects of alcohol.